Advancing Treatment for Elevated Lipoprotein(a)

Lipoprotein (a), otherwise known as Lp(a), is a genetically determined and independent risk factor for heart disease. Elevated Lp(a) is a form of high cholesterol and is different from LDL cholesterol. Having a high Lp(a) level can lead to plaque buildup in the arteries, narrowing of blood vessels, and reduced blood flow. It also increases inflammation and blood clotting, making clots harder for the body to break down.

Many people with high Lp(a) do not have symptoms, which is why cardiologists now recommend that all adults have their Lp(a) level checked with a blood test at least once in their lifetime. Unlike many other heart related risk factors, Lp(a) levels remain relatively stable over time, meaning a single test is usually sufficient to determine your risk.

Although lifestyle changes cannot lower Lp(a) levels, it is still important to reduce your overall risk of heart disease by:

Stopping tobacco use
Maintaining a healthy weight
Eating a heart-healthy diet
Managing risk factors, especially LDL cholesterol
Taking medications as prescribed
Being physically active
Limiting alcohol use
Getting enough sleep

Virginia Heart is fortunate to participate in multiple research trials studying the effects of medications on high Lp(a). Through the Virginia Heart Research Center, led by Dr. Tariq Haddad and Dr. Karan Desai, patients have access to some of the most cutting-edge therapies currently in late-stage clinical trials.

To learn more about the clinical trials Virginia Heart is participating in for Lp(a), talk with your Virginia Heart cardiologist or contact our research team directly at 703-766-5920.

The American Heart Association has also developed several helpful resources that our cardiologists recommend for learning more about Lp(a), including: